As of January 2010, European Medicines Agency (EMA) will no longer accept NeeS (all eSubmissions must be eCTD).
See the eCTD Implementation Survey Report for an update on where the Heads of Agencies stand on complete eCTD acceptance. HMA also provides a useful map showing the status of electronic submissions throughout the EU.
The following table summarizes the eCTD-related guidance documents issued by the EMA:
EMA eCTD Guidance Documents